Chemical Cryptology of Cancer’s Histone Code

Cryptology Unlocked Cryptology Unlocked

Synthetic histone code.

Chromatin is the universal template of genetic information in all eukaryotic cells. This complex of DNA and histone proteins not only packages and organizes genomes but also regulates gene expression. A multitude of posttranslational histone modifications and their combinations are thought to constitute a code for directing distinct structural and functional states of chromatin. Methods of prot...

Translating the histone code.

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for chromatin-associated proteins, which in turn ...

XWH - 09 - 1 - 0109 TITLE : Histone Code Modulation by Oncogenic PWWP - Domain Protein in Breast Cancers

Oncogenic PWWP-domain protein WHSC1L1 links the homeobox transcription factor IRX3 in breast cancer” American Association for Cancer Research Annual Meeting in Washington, DC, April 17-21, 2010

Antibody-free reading of the histone code using a simple chemical sensor array.

The histone code refers to the complex network of histone post-translational modifications that control gene expression and are of high interest as drivers of a large number of human diseases. We report here on a mix-and-match toolkit of readily available dyes and calixarene host molecules that can be combined to form dye-displacement sensors that respond to a wide variety of cationic peptides....